#3990 PACE-CKD: HEALTH-RELATED QUALITY OF LIFE OF PATIENTS WITH CKD AND CAREGIVERS: RESULTS FROM A US SURVEY

Abstract Background and Aims The substantial mortality morbidity burden of chronic kidney disease (CKD) is well described, with the highest associated progression to end-stage (ESKD), where replacement therapy (dialysis or transplantation) indicated. CKD known have a detrimental effect on patient health-related quality life (HRQoL). However, there lack data comparing impact caregiver HRQoL versus general population. This study aimed administer validated instruments using quantitative online survey estimate patients their caregivers compared Method A non-interventional enrolled adult caregivers. Patients diagnosis for at least 3 months were included. ESKD was defined as stage 5 receiving dialysis transplant. Caregivers required not receive formal payment must cared minimum 1 hour week in previous 4 weeks. population cohort also enrolled, matching key demographic characteristics (e.g. age, sex, area residence). Patient assessed EQ-5D-5L instrument. Caregiver measured by CarerQoL-7D carer-specific Results analysis based 199 113 United States who between June July 2022. median age 58 years 38 years, respectively. There 32.2% dialysis, while 81.4% caring dialysis. Most (79.7%) treatment clinic hospital, 20.4% it home. typically parent (45.1%) partner (25.7%) duties would most commonly include driving to/from medical appointments (89.4%). When mean [SD] index scores population, had 33.7% lower utility (0.63 [0.27] vs 0.95 [0.08]) 13.8% (0.81 [0.22]) 0.94 [0.11]) dialysis-dependent (0.59 [0.27]) non (0.65 [0.27]). reported problems across all EQ-5D domains (anxiety depression, mobility, pain/discomfort, selfcare usual activities) when anxiety depression scoring highest. According index, worse than other major illnesses, including hip fractures, breast cancer dementia, according published estimates [1–3]. countries (United Kingdom, Germany Mexico) will be presented congress. Conclusion provides new evidence CKD, both caregivers, incurred detriment HRQoL, which driven domains, particularly depression. Evidence policy interventions should aim slow reduce large societal Funding: supported AstraZeneca.